Treatment Approaches

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What Are the Treatments for CLL?

There are a variety of approved treatments for CLL.1 Some work in different and unique ways, and they are sometimes used in combination with each other.2

There are many factors to consider when you and your doctor discuss which treatment option is best for you, such as3,4:

  • Your overall health status
  • Potential benefits and risks of treatment
  • How different treatments work
  • Genetic testing results
  • How long treatments are taken

It's important to understand the different types of treatment options so you and your doctor can select the treatment that aligns best with your goals.

Commonly Used Treatment Approaches

An orange circle with two test tubes on the inside
Chemotherapy
An orange circle with three antibodies on the inside
Immunotherapy
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Targeted Therapy

 

Common Treatment Options for CLL

The chart below summarizes the treatment regimens commonly used for CLL.

Slide the scroll bar below to view the full chart.

Common First-Line Treatment Regimens for Adults With Previously Untreated CLL11-18

Treatment regimen How it's taken How long it's taken Does it include chemotherapy?
  An icon of a green-blue pill An icon depicting a medical IV bag A black arrow pointing to the right A black calendar icon A black circle indicating that the product is chemotherapy free
  Oral IV Ongoing Set time frame Chemotherapy-free
  Taken by mouth Taken intravenously (through vein) Continues until disease worsens or treatment can no longer be tolerated Taken for a specific amount of time Check mark indicates that treatment regimen does not include chemotherapy
Chemotherapy regimens*          
 
Chemotherapy + CD20 antibody   A black circle with a checkmark inside   A black circle with a checkmark inside  
 
BTK inhibitor regimens          
 
BTK inhibitor alone A black circle with a checkmark inside   A black circle with a checkmark inside   A black circle with a checkmark inside
 
BTK inhibitor + CD20 antibody A black circle with a checkmark inside A black circle with a checkmark inside A black circle with a checkmark inside   A black circle with a checkmark inside
 
BCL-2 inhibitor regimens          
 
BCL-2 inhibitor + CD20 antibody A black circle with a checkmark inside A black circle with a checkmark inside   A black circle with a checkmark inside A black circle with a checkmark inside
 

This is not an exhaustive list of CLL treatment regimens. No claims are made regarding the relative efficacy or safety of each regimen. Treatment decisions are based on complex factors including the overall health of the patient, previous CLL treatments, subtype of CLL, and other considerations. Based on these factors, a doctor may recommend treatments or combinations that are not listed here.3,4

*Chemotherapy can sometimes be dosed orally.1

Common Relapsed/Refractory Treatment Regimens for Adults With Previously Treated CLL12,19-24

Treatment regimen How it's taken How long it's taken Does it include chemotherapy?
  An icon of a green-blue pill An icon depicting a medical IV bag A black arrow pointing to the right A black calendar icon A black circle indicating that the product is chemotherapy free
  Oral IV Ongoing Set time frame Chemotherapy-free
  Taken by mouth Taken intravenously (through vein) Continues until disease worsens or treatment can no longer be tolerated Taken for a specific amount of time Check mark indicates that treatment regimen does not include chemotherapy
Chemotherapy regimens*          
 
Chemotherapy + CD20 antibody   A black circle with a checkmark inside   A black circle with a checkmark inside  
 
BTK inhibitor regimens          
 
BTK inhibitor alone A black circle with a checkmark inside   A black circle with a checkmark inside   A black circle with a checkmark inside
 
PI3K inhibitor regimens          
 
PI3K inhibitor alone A black circle with a checkmark inside   A black circle with a checkmark inside   A black circle with a checkmark inside
 
PI3K inhibitor + CD20 antibody A black circle with a checkmark inside A black circle with a checkmark inside A black circle with a checkmark inside   A black circle with a checkmark inside
 
BCL-2 inhibitor regimens          
 
BCL-2 inhibitor + CD20 antibody A black circle with a checkmark inside A black circle with a checkmark inside   A black circle with a checkmark inside A black circle with a checkmark inside
 

This is not an exhaustive list of CLL treatment regimens. No claims are made regarding the relative efficacy or safety of each regimen. Treatment decisions are based on complex factors including the overall health of the patient, previous CLL treatments, subtype of CLL, and other considerations. Based on these factors, a doctor may recommend treatments or combinations that are not listed here.3,4

If your CLL has returned, the course of treatment your doctor recommends will depend on what treatments you've had before, how long it's been since the last treatment, the genetics of your CLL, and your overall health.

*Chemotherapy can sometimes be dosed orally.1

Talk to your doctor to determine which approach fits best with your CLL treatment goals.

Looking for a CLL Treatment?

Learn about a chemotherapy-free treatment regimen that can be finished in a specific amount of time.

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References

Create your self-care regimen for CLL